Structural highlights
Publication Abstract from PubMed
Thousands of natural products are derived from the fused cyclopentane-pyran molecular scaffold nepetalactol. These natural products are used in an enormous range of applications that span the agricultural and medical industries. For example, nepetalactone, the oxidized derivative of nepetalactol, is known for its cat attractant properties as well as potential as an insect repellent. Most of these naturally occurring nepetalactol-derived compounds arise from only two out of the eight possible stereoisomers, 7S-cis-trans and 7R-cis-cis nepetalactols. Here we use a combination of naturally occurring and engineered enzymes to produce seven of the eight possible nepetalactol or nepetalactone stereoisomers. These enzymes open the possibilities for biocatalytic production of a broader range of iridoids, providing a versatile system for the diversification of this important natural product scaffold.
Biocatalytic routes to stereo-divergent iridoids.,Hernandez Lozada NJ, Hong B, Wood JC, Caputi L, Basquin J, Chuang L, Kunert M, Rodriguez Lopez CE, Langley C, Zhao D, Buell CR, Lichman BR, O'Connor SE Nat Commun. 2022 Aug 11;13(1):4718. doi: 10.1038/s41467-022-32414-w. PMID:35953485[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Hernandez Lozada NJ, Hong B, Wood JC, Caputi L, Basquin J, Chuang L, Kunert M, Rodriguez Lopez CE, Langley C, Zhao D, Buell CR, Lichman BR, O'Connor SE. Biocatalytic routes to stereo-divergent iridoids. Nat Commun. 2022 Aug 11;13(1):4718. doi: 10.1038/s41467-022-32414-w. PMID:35953485 doi:http://dx.doi.org/10.1038/s41467-022-32414-w
