Structural highlights
7qux is a 2 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
|
| Method: | X-ray diffraction, Resolution 1.48Å |
| Ligands: | , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
In this work, an iterative cycle of enzymatic assays, X-ray crystallography, molecular modelling and cellular assays were used to develop a functionalisable chemical probe for the CK2alpha/beta PPI. The lead peptide, P8C9, successfully binds to CK2alpha at the PPI site, is easily synthesisable and functionalisable, highly stable in serum and small enough to accommodate further optimisation.
Development of small cyclic peptides targeting the CK2alpha/beta interface.,Atkinson EL, Iegre J, D'Amore C, Brear P, Salvi M, Hyvonen M, Spring DR Chem Commun (Camb). 2022 Apr 12;58(30):4791-4794. doi: 10.1039/d2cc00707j. PMID:35343996[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Atkinson EL, Iegre J, D'Amore C, Brear P, Salvi M, Hyvonen M, Spring DR. Development of small cyclic peptides targeting the CK2alpha/beta interface. Chem Commun (Camb). 2022 Apr 12;58(30):4791-4794. doi: 10.1039/d2cc00707j. PMID:35343996 doi:http://dx.doi.org/10.1039/d2cc00707j
