7r3g

Structural highlights

Function

RHLR_PSEAE Quorum-sensing regulator that controls the expression of multiple virulence factors in response to extracellular signaling molecules called autoinducers (PubMed:7494482, PubMed:8522523, PubMed:15576196). Involved, among others, in the transcriptional regulation of genes that are responsible for rhamnolipid surfactant biosynthesis (PubMed:8144472, PubMed:7604006, PubMed:14526008). Acts by binding to a specific sequence in the rhlAB regulatory region, both in the presence and in the absence of its autoinducer (PubMed:14526008). In the former case it activates transcription of the promoter, whereas in the latter it acts as a transcriptional repressor (PubMed:14526008). Also regulates the expression of the rmlBDAC operon, encoding dTDP-L-rhamnose biosynthetic enzymes, by binding to the rml box in the promoter region (PubMed:22262098). In addition, is involved in the regulation of the production of elastase (lasB) and pyocyanine (PubMed:8144472, PubMed:7604006, PubMed:8522523).^{[1] [2] [3] [4] [5] [6] [7]}

References

1. ↑ Medina G, Juarez K, Valderrama B, Soberon-Chavez G. Mechanism of Pseudomonas aeruginosa RhlR transcriptional regulation of the rhlAB promoter. J Bacteriol. 2003 Oct;185(20):5976-83. doi: 10.1128/JB.185.20.5976-5983.2003. PMID:14526008 doi:http://dx.doi.org/10.1128/JB.185.20.5976-5983.2003
2. ↑ Wagner VE, Gillis RJ, Iglewski BH. Transcriptome analysis of quorum-sensing regulation and virulence factor expression in Pseudomonas aeruginosa. Vaccine. 2004 Dec 6;22 Suppl 1:S15-20. doi: 10.1016/j.vaccine.2004.08.011. PMID:15576196 doi:http://dx.doi.org/10.1016/j.vaccine.2004.08.011
3. ↑ Aguirre-Ramirez M, Medina G, Gonzalez-Valdez A, Grosso-Becerra V, Soberon-Chavez G. The Pseudomonas aeruginosa rmlBDAC operon, encoding dTDP-L-rhamnose biosynthetic enzymes, is regulated by the quorum-sensing transcriptional regulator RhlR and the alternative sigma factor sigmaS. Microbiology (Reading). 2012 Apr;158(Pt 4):908-916. doi: 10.1099/mic.0.054726-0. , Epub 2012 Jan 19. PMID:22262098 doi:http://dx.doi.org/10.1099/mic.0.054726-0
4. ↑ Latifi A, Winson MK, Foglino M, Bycroft BW, Stewart GS, Lazdunski A, Williams P. Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1. Mol Microbiol. 1995 Jul;17(2):333-43. doi: , 10.1111/j.1365-2958.1995.mmi_17020333.x. PMID:7494482 doi:http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_17020333.x
5. ↑ Ochsner UA, Reiser J. Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6424-8. PMID:7604006
6. ↑ Ochsner UA, Koch AK, Fiechter A, Reiser J. Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. J Bacteriol. 1994 Apr;176(7):2044-54. doi: 10.1128/jb.176.7.2044-2054.1994. PMID:8144472 doi:http://dx.doi.org/10.1128/jb.176.7.2044-2054.1994
7. ↑ Brint JM, Ohman DE. Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family. J Bacteriol. 1995 Dec;177(24):7155-63. PMID:8522523