7r7j
From Proteopedia
Crystal structure of RadD with ADP
Structural highlights
FunctionRADD_ECOLI May be a helicase. In combination with RadA is important in repair of double-strand DNA breaks (DSB) (PubMed:25425430, PubMed:25484163).[1] [2] Publication Abstract from PubMedGenome maintenance is an essential process in all cells. In prokaryotes, the RadD protein is important for survival under conditions that include DNA-damaging radiation. Precisely how RadD participates in genome maintenance remains unclear. Here we present a high-resolution X-ray crystal structure of ADP-bound Escherichia coli RadD, revealing a zinc-ribbon element that was not modelled in a previous RadD crystal structure. Insights into the mode of nucleotide binding and additional structure refinement afforded by the new RadD model will help to drive investigations into the activity of RadD as a genome stability and repair factor. X-ray crystal structure of the Escherichia coli RadD DNA repair protein bound to ADP reveals a novel zinc ribbon domain.,Osorio Garcia MA, Satyshur KA, Cox MM, Keck JL PLoS One. 2022 Apr 28;17(4):e0266031. doi: 10.1371/journal.pone.0266031., eCollection 2022. PMID:35482735[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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