Structural highlights
7rww is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.7Å |
| Ligands: | , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
C562_ECOLX Electron-transport protein of unknown function.
Publication Abstract from PubMed
Herein we describe a designed protein building block whose self-assembly behaviour is dually gated by the redox state of disulphide bonds and the identity of exogenous metal ions. This protein construct is shown - through extensive structural and biophysical characterization - to access five distinct oligomeric states, exemplifying how the complex interplay between hydrophobic, metal-ligand, and reversible covalent interactions could be harnessed to obtain multiple, responsive protein architectures from a single building block.
Redox- and metal-directed structural diversification in designed metalloprotein assemblies.,Kakkis A, Golub E, Choi TS, Tezcan FA Chem Commun (Camb). 2022 Jun 16;58(49):6958-6961. doi: 10.1039/d2cc02440c. PMID:35642584[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Kakkis A, Golub E, Choi TS, Tezcan FA. Redox- and metal-directed structural diversification in designed metalloprotein assemblies. Chem Commun (Camb). 2022 Jun 16;58(49):6958-6961. doi: 10.1039/d2cc02440c. PMID:35642584 doi:http://dx.doi.org/10.1039/d2cc02440c
