7sb8

Publication Abstract from PubMed

DNA can adopt noncanonical structures that have important biological functions while also providing structural diversity for applications in nanotechnology. Here, the crystal structures of two oligonucleotides composed of d(CGA) triplet repeats in the parallel-stranded duplex form are described. The structure determination of four unique d(CGA)-based parallel-stranded duplexes across two crystal structures has allowed the structural parameters of d(CGA) triplets in the parallel-stranded duplex form to be characterized and established. These results show that d(CGA) units are highly uniform, but that each strand in the duplex is structurally unique and has a distinct role in accommodating structural asymmetries induced by the C-CH(+) base pair.

The parallel-stranded d(CGA) duplex is a highly predictable structural motif with two conformationally distinct strands.,Luteran EM, Paukstelis PJ Acta Crystallogr D Struct Biol. 2022 Mar 1;78(Pt 3):299-309. doi:, 10.1107/S2059798322000304. Epub 2022 Feb 18. PMID:35234144^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.