7stg

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Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity

Structural highlights

7stg is a 32 chain structure with sequence from Homo sapiens, Lama glama and Pongo pygmaeus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RADX_HUMAN Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897).[1] A0A678ZGP6_HUMAN B2MG_PONPY Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).

References

  1. ↑ Dungrawala H, Bhat KP, Le Meur R, Chazin WJ, Ding X, Sharan SK, Wessel SR, Sathe AA, Zhao R, Cortez D. RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks. Mol Cell. 2017 Aug 3;67(3):374-386.e5. doi: 10.1016/j.molcel.2017.06.023. Epub , 2017 Jul 20. PMID:28735897 doi:http://dx.doi.org/10.1016/j.molcel.2017.06.023

Contents


PDB ID 7stg

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OCA

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