7t02

Structural highlights

Function

DMT5_CRYNH ATP-dependent cytosine methylase that maintains DNA methylation by acting at hemimethylated palindromic 5'-CG-3' sites to produce symmetrically methylated DNA strands (PubMed:24630728, PubMed:31955845, PubMed:32437639). DNA methylation may play a role in transcriptional silencing, particularly at transposable elements (PubMed:24630728).^{[1] [2] [3] [4]}

References

1. ↑ Huff JT, Zilberman D. Dnmt1-independent CG methylation contributes to nucleosome positioning in diverse eukaryotes. Cell. 2014 Mar 13;156(6):1286-1297. doi: 10.1016/j.cell.2014.01.029. PMID:24630728 doi:http://dx.doi.org/10.1016/j.cell.2014.01.029
2. ↑ Catania S, Dumesic PA, Pimentel H, Nasif A, Stoddard CI, Burke JE, Diedrich JK, Cook S, Shea T, Geinger E, Lintner R, Yates JR 3rd, Hajkova P, Narlikar GJ, Cuomo CA, Pritchard JK, Madhani HD. Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase. Cell. 2020 Jan 23;180(2):263-277.e20. doi: 10.1016/j.cell.2019.12.012. Epub 2020 , Jan 16. PMID:31955845 doi:http://dx.doi.org/10.1016/j.cell.2019.12.012
3. ↑ Dumesic PA, Stoddard CI, Catania S, Narlikar GJ, Madhani HD. ATP Hydrolysis by the SNF2 Domain of Dnmt5 Is Coupled to Both Specific Recognition and Modification of Hemimethylated DNA. Mol Cell. 2020 Jul 2;79(1):127-139.e4. doi: 10.1016/j.molcel.2020.04.029. Epub, 2020 May 20. PMID:32437639 doi:http://dx.doi.org/10.1016/j.molcel.2020.04.029
4. ↑ Huff JT, Zilberman D. Dnmt1-independent CG methylation contributes to nucleosome positioning in diverse eukaryotes. Cell. 2014 Mar 13;156(6):1286-1297. doi: 10.1016/j.cell.2014.01.029. PMID:24630728 doi:http://dx.doi.org/10.1016/j.cell.2014.01.029