7t6d

Structural highlights

Function

LAPB_ECOLI Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.[HAMAP-Rule:MF_00994]^{[1] [2]}

References

1. ↑ Mahalakshmi S, Sunayana MR, SaiSree L, Reddy M. yciM is an essential gene required for regulation of lipopolysaccharide synthesis in Escherichia coli. Mol Microbiol. 2014 Jan;91(1):145-57. PMID:24266962 doi:10.1111/mmi.12452
2. ↑ Klein G, Kobylak N, Lindner B, Stupak A, Raina S. Assembly of lipopolysaccharide in Escherichia coli requires the essential LapB heat shock protein. J Biol Chem. 2014 May 23;289(21):14829-53. PMID:24722986 doi:10.1074/jbc.M113.539494