7tb9

Structural highlights

Function

CEMP1_HUMAN May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum (PubMed:21929512, PubMed:17509525, PubMed:21465469). Binds hydroxyapatite and may promote the biomineralization of the cementum (PubMed:19393626). Also promotes cell proliferation (PubMed:17509525, PubMed:21929512, PubMed:26011628).^{[1] [2] [3] [4] [5]}

References

1. ↑ Carmona-Rodriguez B, Alvarez-Perez MA, Narayanan AS, Zeichner-David M, Reyes-Gasga J, Molina-Guarneros J, Garcia-Hernandez AL, Suarez-Franco JL, Chavarria IG, Villarreal-Ramirez E, Arzate H. Human Cementum Protein 1 induces expression of bone and cementum proteins by human gingival fibroblasts. Biochem Biophys Res Commun. 2007 Jul 6;358(3):763-9. doi: , 10.1016/j.bbrc.2007.04.204. Epub 2007 May 11. PMID:17509525 doi:http://dx.doi.org/10.1016/j.bbrc.2007.04.204
2. ↑ Villarreal-Ramirez E, Moreno A, Mas-Oliva J, Chavez-Pacheco JL, Narayanan AS, Gil-Chavarria I, Zeichner-David M, Arzate H. Characterization of recombinant human cementum protein 1 (hrCEMP1): primary role in biomineralization. Biochem Biophys Res Commun. 2009 Jun 19;384(1):49-54. doi: , 10.1016/j.bbrc.2009.04.072. Epub 2009 Apr 23. PMID:19393626 doi:http://dx.doi.org/10.1016/j.bbrc.2009.04.072
3. ↑ Komaki M, Iwasaki K, Arzate H, Narayanan AS, Izumi Y, Morita I. Cementum protein 1 (CEMP1) induces a cementoblastic phenotype and reduces osteoblastic differentiation in periodontal ligament cells. J Cell Physiol. 2012 Feb;227(2):649-57. doi: 10.1002/jcp.22770. PMID:21465469 doi:http://dx.doi.org/10.1002/jcp.22770
4. ↑ Hoz L, Romo E, Zeichner-David M, Sanz M, Nunez J, Gaitan L, Mercado G, Arzate H. Cementum protein 1 (CEMP1) induces differentiation by human periodontal ligament cells under three-dimensional culture conditions. Cell Biol Int. 2012 Feb;36(2):129-36. doi: 10.1042/CBI20110168. PMID:21929512 doi:http://dx.doi.org/10.1042/CBI20110168
5. ↑ Bermudez M, Imaz-Rosshandler I, Rangel-Escareno C, Zeichner-David M, Arzate H, Mercado-Celis GE. CEMP1 Induces Transformation in Human Gingival Fibroblasts. PLoS One. 2015 May 26;10(5):e0127286. doi: 10.1371/journal.pone.0127286. , eCollection 2015. PMID:26011628 doi:http://dx.doi.org/10.1371/journal.pone.0127286