7u8c
From Proteopedia
Crystal structure of Mesothelin C-terminal peptide-MORAb 15B6 FAB complex
Structural highlights
DiseaseMSLN_HUMAN Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. FunctionMSLN_HUMAN Membrane-anchored forms may play a role in cellular adhesion.[1] [2] Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.[3] [4] Publication Abstract from PubMedSignificanceMesothelin (MSLN) is a cell-surface protein that is a popular target for antibody-based therapies. We have identified shed MSLN as a major obstacle to successful antibody therapies and prepared a monoclonal antibody that inhibits shedding and makes very active CAR T cells whose activity is not blocked by shed MSLN and merits further preclinical development. Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin.,Liu X, Onda M, Watson N, Hassan R, Ho M, Bera TK, Wei J, Chakraborty A, Beers R, Zhou Q, Shajahan A, Azadi P, Zhan J, Xia D, Pastan I Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2202439119. doi: , 10.1073/pnas.2202439119. Epub 2022 May 5. PMID:35512094[5] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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Categories: Homo sapiens | Large Structures | Mus musculus | Esser L | Xia D | Zhan J
