Structural highlights
Function
3L255_OPHHA Binds to muscular and neuronal nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission (PubMed:35341214). Pseudo-irreversibly inhibits twitches in chick biventer cervicis nerve-muscle preparations in a concentration-dependent manner (PubMed:35341214).[1]
References
- ↑ Huynh TM, Silva A, Isbister GK, Hodgson WC. Isolation and Pharmacological Characterization of α-Elapitoxin-Oh3a, a Long-Chain Post-Synaptic Neurotoxin From King Cobra (Ophiophagus hannah) Venom. Front Pharmacol. 2022 Mar 7;13:815069. PMID:35341214 doi:10.3389/fphar.2022.815069
