Structural highlights
Function
DOTY_LEGPH Component of the Dot/Icm type IVB secretion system (T4BSS), which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:32513920). Part of a subcomplex which recruits effector proteins and delivers them to the core transmembrane subcomplex (PubMed:32513920). DotY and DotZ play a role in effector translocation, but are not essential and do not influence the stability of the subcomplex main components (PubMed:34816517). The DotY/DotZ main function is to optimize secretion by modulating the delivery trajectory of the IcmSW module and the localization of the machinery to the poles (PubMed:34816517).[1] [2]
References
- ↑ Meir A, Mace K, Lukoyanova N, Chetrit D, Hospenthal MK, Redzej A, Roy C, Waksman G. Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila. Nat Commun. 2020 Jun 8;11(1):2864. doi: 10.1038/s41467-020-16681-z. PMID:32513920 doi:http://dx.doi.org/10.1038/s41467-020-16681-z
- ↑ Macé K, Meir A, Lukoyanova N, Liu L, Chetrit D, Hospenthal MK, Roy CR, Waksman G. Proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila. Mol Microbiol. 2022 Feb;117(2):307-319. PMID:34816517 doi:10.1111/mmi.14847
