7vbt

Structural highlights

Function

RIOK2_HUMAN Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).^{[1] [2] [3]}

See Also

• Serine/threonine protein kinase 3D structures

References

1. ↑ Rouquette J, Choesmel V, Gleizes PE. Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells. EMBO J. 2005 Aug 17;24(16):2862-72. doi: 10.1038/sj.emboj.7600752. Epub 2005 Jul , 28. PMID:16037817 doi:http://dx.doi.org/10.1038/sj.emboj.7600752
2. ↑ Zemp I, Wild T, O'Donohue MF, Wandrey F, Widmann B, Gleizes PE, Kutay U. Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2. J Cell Biol. 2009 Jun 29;185(7):1167-80. PMID:19564402 doi:http://dx.doi.org/jcb.200904048
3. ↑ Liu T, Deng M, Li J, Tong X, Wei Q, Ye X. Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression. J Biol Chem. 2011 Oct 21;286(42):36352-60. doi: 10.1074/jbc.M111.250175. Epub, 2011 Aug 31. PMID:21880710 doi:http://dx.doi.org/10.1074/jbc.M111.250175