7w9h

Structural highlights

Function

FLER_PSEAE Member of the two-component regulatory system FleS/FleR that regulates the expression of multiple genes involved in flagellar synthesis, adhesion, swarming, motility and antibiotic resistance (PubMed:7591148, PubMed:30877999, PubMed:8876537). May function as a transcriptional activator by direct binding to a cis-acting sequence upstream of the target genes (Probable).^{[1] [2] [3] [4]}

See Also

• Response regulator 3D structure

References

1. ↑ Kollaran AM, Joge S, Kotian HS, Badal D, Prakash D, Mishra A, Varma M, Singh V. Context-Specific Requirement of Forty-Four Two-Component Loci in Pseudomonas aeruginosa Swarming. iScience. 2019 Mar 29;13:305-317. doi: 10.1016/j.isci.2019.02.028. Epub 2019 Mar , 1. PMID:30877999 doi:http://dx.doi.org/10.1016/j.isci.2019.02.028
2. ↑ Ritchings BW, Almira EC, Lory S, Ramphal R. Cloning and phenotypic characterization of fleS and fleR, new response regulators of Pseudomonas aeruginosa which regulate motility and adhesion to mucin. Infect Immun. 1995 Dec;63(12):4868-76. PMID:7591148
3. ↑ Ramphal R, Arora SK, Ritchings BW. Recognition of mucin by the adhesin-flagellar system of Pseudomonas aeruginosa. Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 2):S170-4. doi: , 10.1164/ajrccm/154.4_Pt_2.S170. PMID:8876537 doi:http://dx.doi.org/10.1164/ajrccm/154.4_Pt_2.S170
4. ↑ Ritchings BW, Almira EC, Lory S, Ramphal R. Cloning and phenotypic characterization of fleS and fleR, new response regulators of Pseudomonas aeruginosa which regulate motility and adhesion to mucin. Infect Immun. 1995 Dec;63(12):4868-76. PMID:7591148