7x1r
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proteopedia linkproteopedia linkCryo-EM structure of human thioredoxin reductase bound by Au
Structural highlights
FunctionTRXR1_HUMAN Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.[1] [2] [3] [4] See AlsoReferences
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Categories: Homo sapiens | Large Structures | Cao P | Cao SH | Gao XY | Gong Y | He B | He ZS | Jiang HD