7x43

Structural highlights

Function

CTXL_LEIQU This toxin binds to the surface of glioma cells, and inhibits their proliferation without having effects on normal brain cells. In this context, this toxin has been described as a chloride channel inhibitor (probably ClC-3/CLCN3) by causing its internalization via caveolae (PubMed:16520829). It has also been described to selectively interact with MMP2 (in complex with MT1-MMP (MMP14) and TIMP2), to inhibit its enzymatic activity and to decrease its presence at the cell surface (PubMed:12454020).^{[1] [2] [3]}

References

1. ↑ Deshane J, Garner CC, Sontheimer H. Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2. J Biol Chem. 2003 Feb 7;278(6):4135-44. Epub 2002 Nov 25. PMID:12454020 doi:http://dx.doi.org/10.1074/jbc.M205662200
2. ↑ McFerrin MB, Sontheimer H. A role for ion channels in glioma cell invasion. Neuron Glia Biol. 2006 Feb;2(1):39-49. PMID:16520829 doi:http://dx.doi.org/10.1017/S17440925X06000044
3. ↑ DeBin JA, Maggio JE, Strichartz GR. Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. Am J Physiol. 1993 Feb;264(2 Pt 1):C361-9. PMID:8383429