7x6h

Structural highlights

Function

QSEG_ECO57 Involved in the regulation of virulence and metabolism in EHEC. Required for pedestal formation in host epithelial cells during infection. Necessary for translocation of effector molecules into host epithelial cells, but is not involved in structural assembly of the type III secretion system (TTSS).^{[1] [2]}

References

1. ↑ Reading NC, Rasko DA, Torres AG, Sperandio V. The two-component system QseEF and the membrane protein QseG link adrenergic and stress sensing to bacterial pathogenesis. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5889-94. PMID:19289831 doi:10.1073/pnas.0811409106
2. ↑ Reading NC, Rasko D, Torres AG, Sperandio V. A transcriptome study of the QseEF two-component system and the QseG membrane protein in enterohaemorrhagic Escherichia coli O157 : H7. Microbiology (Reading). 2010 Apr;156(Pt 4):1167-1175. PMID:20056703 doi:10.1099/mic.0.033027-0