7xg9

Structural highlights

Function

METF_SPHSK Catalyzes the NADH-dependent reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. Is required to provide the methyl group necessary for methionine synthetase to convert homocysteine to methionine; the methyl group is given by 5-methyltetrahydrofolate (By similarity). Is required for Sphingobium SYK-6 to grow on vanillate or syringate as the sole source of carbon (Ref.3).[UniProtKB:P0AEZ1][REFERENCE:3]

See Also

• Methylenetetrahydrofolate reductase 3D structures