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Structural highlights

Disease

S26A3_HUMAN Congenital chloride diarrhea. The disease is caused by variants affecting the gene represented in this entry.

Function

S26A3_HUMAN Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).[UniProtKB:Q9WVC8]^{[1] [2] [3] [4]}

References

1. ↑ Shcheynikov N, Wang Y, Park M, Ko SB, Dorwart M, Naruse S, Thomas PJ, Muallem S. Coupling modes and stoichiometry of Cl-/HCO3 J Gen Physiol. 2006 May;127(5):511-24. PMID:16606687 doi:10.1085/jgp.200509392
2. ↑ Hayashi H, Suruga K, Yamashita Y. Regulation of intestinal Cl-/HCO3 Am J Physiol Cell Physiol. 2009 Jun;296(6):C1279-90. PMID:19321737 doi:10.1152/ajpcell.00638.2008
3. ↑ Hayashi H, Yamashita Y. Role of N-glycosylation in cell surface expression and protection against proteolysis of the intestinal anion exchanger SLC26A3. Am J Physiol Cell Physiol. 2012 Mar 1;302(5):C781-95. PMID:22159084 doi:10.1152/ajpcell.00165.2011
4. ↑ Lee JH, Nam JH, Park J, Kang DW, Kim JY, Lee MG, Yoon JS. Regulation of SLC26A3 activity by NHERF4 PDZ-mediated interaction. Cell Signal. 2012 Sep;24(9):1821-30. PMID:22627094 doi:10.1016/j.cellsig.2012.05.010