7ykr

Structural highlights

Function

TRPA1_DROME Essential for thermotaxis by sensing environmental temperature. Receptor-activated non-selective cation channel involved in detection of sensations such as temperature. Involved in heat nociception by being activated by warm temperature of about 24-29 degrees Celsius.^{[1] [2]}

References

1. ↑ Viswanath V, Story GM, Peier AM, Petrus MJ, Lee VM, Hwang SW, Patapoutian A, Jegla T. Opposite thermosensor in fruitfly and mouse. Nature. 2003 Jun 19;423(6942):822-3. PMID:12815418 doi:10.1038/423822a
2. ↑ Rosenzweig M, Brennan KM, Tayler TD, Phelps PO, Patapoutian A, Garrity PA. The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. Genes Dev. 2005 Feb 15;19(4):419-24. PMID:15681611 doi:10.1101/gad.1278205