7z05

Structural highlights

Function

R1AB_WBV24 The 3C-like serine proteinase is responsible for the majority of cleavages. The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction. NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.