8a4r

Structural highlights

Function

PRAC_ACESD Catalyzes the reversible interconversion of L- and D-proline (PubMed:5722267, PubMed:24314397). Likely functions as the proline racemase necessary for D-proline generation in order to discriminate it from the L-proline used for protein synthesis (PubMed:20937090).^{[1] [2] [3]}

References

1. ↑ Harty M, Nagar M, Atkinson L, Legay CM, Derksen DJ, Bearne SL. Inhibition of serine and proline racemases by substrate-product analogues. Bioorg Med Chem Lett. 2014 Jan 1;24(1):390-3. PMID:24314397 doi:10.1016/j.bmcl.2013.10.061
2. ↑ Cardinale GJ, Abeles RH. Purification and mechanism of action of proline racemase. Biochemistry. 1968 Nov;7(11):3970-8. PMID:5722267 doi:10.1021/bi00851a026
3. ↑ Fonknechten N, Chaussonnerie S, Tricot S, Lajus A, Andreesen JR, Perchat N, Pelletier E, Gouyvenoux M, Barbe V, Salanoubat M, Le Paslier D, Weissenbach J, Cohen GN, Kreimeyer A. Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome sequence. BMC Genomics. 2010 Oct 11;11:555. PMID:20937090 doi:10.1186/1471-2164-11-555