Structural highlights
Disease
KALRN_HUMAN Disease susceptibility is associated with variations affecting the gene represented in this entry.
Function
KALRN_HUMAN Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.[1]
References
- ↑ Kawai T, Sanjo H, Akira S. Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains. Gene. 1999 Feb 18;227(2):249-55. doi: 10.1016/s0378-1119(98)00605-2. PMID:10023074 doi:http://dx.doi.org/10.1016/s0378-1119(98)00605-2
