Structural highlights
Disease
TET5A_HUMAN Osteogenesis imperfecta type 3. The disease is caused by variants affecting the gene represented in this entry.
Function
TET5A_HUMAN Cytoplasmic non-canonical poly(A) RNA polymerase that catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and participates in the cytoplasmic polyadenylation (PubMed:33882302). Polyadenylates mRNA encoding extracellular matrix constituents and other genes crucial for bone mineralization and during osteoblast mineralization, mainly focuses on ER-targeted mRNAs (By similarity).[UniProtKB:D3Z5S8][1]
References
- ↑ Gewartowska O, Aranaz-Novaliches G, Krawczyk PS, Mroczek S, Kusio-Kobiałka M, Tarkowski B, Spoutil F, Benada O, Kofroňová O, Szwedziak P, Cysewski D, Gruchota J, Szpila M, Chlebowski A, Sedlacek R, Prochazka J, Dziembowski A. Cytoplasmic polyadenylation by TENT5A is required for proper bone formation. Cell Rep. 2021 Apr 20;35(3):109015. PMID:33882302 doi:10.1016/j.celrep.2021.109015
