Structural highlights
Function
YHEH_BACSU Involved in the transport of four structurally unrelated drugs, including doxorubicin and mitoxantrone. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation.[1]
References
- ↑ Torres C, Galián C, Freiberg C, Fantino JR, Jault JM. The YheI/YheH heterodimer from Bacillus subtilis is a multidrug ABC transporter. Biochim Biophys Acta. 2009 Mar;1788(3):615-22. PMID:19167342 doi:10.1016/j.bbamem.2008.12.012
