Structural highlights
Function
A0A0B5CMT4_9VIRU
Publication Abstract from PubMed
Replication initiator proteins (Reps) from the HUH endonuclease family process specific single-stranded DNA sequences to initiate rolling-circle replication in viruses. Here, the first crystal structure of the apo state of a Rep domain from the smacovirus family is reported. The structure of the human smacovirus 1 Rep domain was obtained at 1.33 A resolution and represents an expansion of the HUH endonuclease superfamily, allowing greater diversity in bioconjugation-tag applications.
The crystal structure of the human smacovirus 1 Rep domain.,Limon LK, Shi K, Dao A, Rugloski J, Tompkins KJ, Aihara H, Gordon WR, Evans RL 3rd Acta Crystallogr F Struct Biol Commun. 2023 Dec 1;79(Pt 12):295-300. doi: , 10.1107/S2053230X23009536. Epub 2023 Dec 5. PMID:38051309[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Limón LK, Shi K, Dao A, Rugloski J, Tompkins KJ, Aihara H, Gordon WR, Evans RL 3rd. The crystal structure of the human smacovirus 1 Rep domain. Acta Crystallogr F Struct Biol Commun. 2023 Dec 1;79(Pt 12):295-300. PMID:38051309 doi:10.1107/S2053230X23009536
