Structural highlights
Function
NEC2_HHV11 Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.[HAMAP-Rule:MF_04024][1] [2] [3]
References
- ↑ Bjerke SL, Cowan JM, Kerr JK, Reynolds AE, Baines JD, Roller RJ. Effects of charged cluster mutations on the function of herpes simplex virus type 1 UL34 protein. J Virol. 2003 Jul;77(13):7601-10. PMID:12805460
- ↑ Reynolds AE, Liang L, Baines JD. Conformational changes in the nuclear lamina induced by herpes simplex virus type 1 require genes U(L)31 and U(L)34. J Virol. 2004 Jun;78(11):5564-75. PMID:15140953 doi:http://dx.doi.org/10.1128/JVI.78.11.5564-5575.2004
- ↑ Simpson-Holley M, Baines J, Roller R, Knipe DM. Herpes simplex virus 1 U(L)31 and U(L)34 gene products promote the late maturation of viral replication compartments to the nuclear periphery. J Virol. 2004 Jun;78(11):5591-600. PMID:15140956 doi:http://dx.doi.org/10.1128/JVI.78.11.5591-5600.2004
