Structural highlights
Function
L7R9I1_HBV
Publication Abstract from PubMed
The HBV capsid core protein serves a number of important functions in the viral life cycle enabling chronic HBV infection to persist, and therefore is a promising drug target. Interfering with capsid assembly has shown efficacy in clinical trials with small molecule capsid assembly modulators (CAMs). Herein is described the further optimization of a progressive series of diazepinone HBV CAMs.
Diazepinone HBV capsid assembly modulators.,Kuduk SD, DeRatt LG, Stoops B, Shaffer P, Lam AM, Espiritu C, Vogel R, Lau V, Flores OA, Hartman GD Bioorg Med Chem Lett. 2022 Sep 15;72:128823. doi: 10.1016/j.bmcl.2022.128823. , Epub 2022 May 27. PMID:35644301[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Kuduk SD, DeRatt LG, Stoops B, Shaffer P, Lam AM, Espiritu C, Vogel R, Lau V, Flores OA, Hartman GD. Diazepinone HBV capsid assembly modulators. Bioorg Med Chem Lett. 2022 Sep 15;72:128823. PMID:35644301 doi:10.1016/j.bmcl.2022.128823
