8gmy

Structural highlights

Function

SAMTR_DROME S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling (PubMed:29123071, PubMed:35776786). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1 (PubMed:29123071, PubMed:35776786). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.[HAMAP-Rule:MF_03044]^{[1] [2]}

References

1. ↑ Gu X, Orozco JM, Saxton RA, Condon KJ, Liu GY, Krawczyk PA, Scaria SM, Harper JW, Gygi SP, Sabatini DM. SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway. Science. 2017 Nov 10;358(6364):813-818. doi: 10.1126/science.aao3265. PMID:29123071 doi:http://dx.doi.org/10.1126/science.aao3265
2. ↑ Tang X, Zhang Y, Wang G, Zhang C, Wang F, Shi J, Zhang T, Ding J. Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling. Sci Adv. 2022 Jul;8(26):eabn3868. PMID:35776786 doi:10.1126/sciadv.abn3868