Structural highlights
Function
ESSD_STAA8 Component of the type VII secretion system (Ess). Plays a role in Ess secretion during infection. Required for the efficient secretion of EsxA. Required for abscess formation and staphylococcal persistence in host tissues (By similarity). Possesses a toxic DNase activity that is modulated by EssG by forming a nuclease toxin-antitoxin pair. This nuclease toxin targets competitor bacteria (PubMed:27723728).[UniProtKB:A0A0H2XIV9][1]
References
- ↑ Cao Z, Casabona MG, Kneuper H, Chalmers JD, Palmer T. The type VII secretion system of Staphylococcus aureus secretes a nuclease toxin that targets competitor bacteria. Nat Microbiol. 2016 Oct 10;2:16183. doi: 10.1038/nmicrobiol.2016.183. PMID:27723728 doi:http://dx.doi.org/10.1038/nmicrobiol.2016.183
