8hqa

Structural highlights

Function

MLAD_ECOLI Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane (PubMed:19383799, PubMed:27529189). MlaD functions in substrate binding with strong affinity for phospholipids and modulates ATP hydrolytic activity of the complex (PubMed:27529189).^{[1] [2]}

References

1. ↑ Malinverni JC, Silhavy TJ. An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane. Proc Natl Acad Sci U S A. 2009 May 12;106(19):8009-14. doi:, 10.1073/pnas.0903229106. Epub 2009 Apr 21. PMID:19383799 doi:http://dx.doi.org/10.1073/pnas.0903229106
2. ↑ Thong S, Ercan B, Torta F, Fong ZY, Wong HY, Wenk MR, Chng SS. Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry. Elife. 2016 Aug 16;5:e19042. PMID:27529189 doi:10.7554/eLife.19042