8hs7

Structural highlights

Function

SCS2_YEAST Targets proteins containing a FFAT motif to endoplasmic reticulum membranes. Regulates phospholipid biosynthesis by modulating the subcellular localization of the transcriptional repressor OPI1.^{[1] [2]}

References

1. ↑ Loewen CJ, Roy A, Levine TP. A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP. EMBO J. 2003 May 1;22(9):2025-35. PMID:12727870 doi:10.1093/emboj/cdg201
2. ↑ Loewen CJ, Levine TP. A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. J Biol Chem. 2005 Apr 8;280(14):14097-104. PMID:15668246 doi:10.1074/jbc.M500147200