Structural highlights
Function
PYRG_DROME Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). Isoform 1 is required for cytoophidium assembly in female germline cells.[1]
References
- ↑ Azzam G, Liu JL. Only one isoform of Drosophila melanogaster CTP synthase forms the cytoophidium. PLoS Genet. 2013;9(2):e1003256. doi: 10.1371/journal.pgen.1003256. Epub 2013 Feb , 14. PMID:23459760 doi:http://dx.doi.org/10.1371/journal.pgen.1003256
