8ip5

Structural highlights

Function

MRS2_HUMAN Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).^{[1] [2]}

References

1. ↑ Zsurka G, Gregán J, Schweyen RJ. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. Genomics. 2001 Mar 1;72(2):158-68. PMID:11401429 doi:10.1006/geno.2000.6407
2. ↑ Piskacek M, Zotova L, Zsurka G, Schweyen RJ. Conditional knockdown of hMRS2 results in loss of mitochondrial Mg(2+) uptake and cell death. J Cell Mol Med. 2009 Apr;13(4):693-700. PMID:18384665 doi:10.1111/j.1582-4934.2008.00328.x