8irj
From Proteopedia
Cryo-EM structure of an orphan GPCR
Structural highlights
DiseaseGP179_HUMAN Congenital stationary night blindness. The disease is caused by variants affecting the gene represented in this entry. FunctionGP179_HUMAN Orphan receptor involved in vision (PubMed:22325362, PubMed:24084093). Required for signal transduction through retinal depolarizing bipolar cells (PubMed:22325362). Acts as an atypical G-protein coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1 (By similarity).[UniProtKB:E9PY61][1] [2] References
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Categories: Homo sapiens | Large Structures | Jeong H | Lee HH | Yun Y