8is0

Structural highlights

Function

EGTE_MYCS2 Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine. Ergothioneine is a secreted antioxidant that protects mycobacterium from oxidative stress.^{[1] [2]}

References

1. ↑ Seebeck FP. In vitro reconstitution of Mycobacterial ergothioneine biosynthesis. J Am Chem Soc. 2010 May 19;132(19):6632-3. doi: 10.1021/ja101721e. PMID:20420449 doi:http://dx.doi.org/10.1021/ja101721e
2. ↑ Sao Emani C, Williams MJ, Wiid IJ, Hiten NF, Viljoen AJ, Pietersen RD, van Helden PD, Baker B. Ergothioneine is a secreted antioxidant in Mycobacterium smegmatis. Antimicrob Agents Chemother. 2013 Jul;57(7):3202-7. PMID:23629716 doi:10.1128/AAC.02572-12