8kb4

Structural highlights

Function

TM87A_HUMAN May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN) (PubMed:26157166). In one study, shown to be a component of a novel mechanoelectrical transduction pathway which is involved in cell adhesion and migration, and is thought to act either as a mechanically activated ion channel or as an accessory protein which modulates an unidentified mechanically activated ion channel (PubMed:32228863). In another study, neither basal nor mechanically activated channel activity has been observed and, based on structural similarity with WLS, has been suggested to function as a trafficking chaperone for membrane-associated cargo (PubMed:36373655).^{[1] [2] [3]}

References

1. ↑ Hirata T, Fujita M, Nakamura S, Gotoh K, Motooka D, Murakami Y, Maeda Y, Kinoshita T. Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport. Mol Biol Cell. 2015 Sep 1;26(17):3071-84. doi: 10.1091/mbc.E14-11-1568. Epub 2015, Jul 8. PMID:26157166 doi:http://dx.doi.org/10.1091/mbc.E14-11-1568
2. ↑ Patkunarajah A, Stear JH, Moroni M, Schroeter L, Blaszkiewicz J, Tearle JL, Cox CD, Fürst C, Sánchez-Carranza O, Ocaña Fernández MDÁ, Fleischer R, Eravci M, Weise C, Martinac B, Biro M, Lewin GR, Poole K. TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration. Elife. 2020 Apr 1;9:e53308. PMID:32228863 doi:10.7554/eLife.53308
3. ↑ Hoel CM, Zhang L, Brohawn SG. Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A. Elife. 2022 Nov 14;11:e81704. PMID:36373655 doi:10.7554/eLife.81704