8ork

Structural highlights

Function

CPGS_METFV Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. It is also able to catalyze the hydrolysis of cDPG but with significant slower rates (8-10 times). May be involved in thermoadaptation.^{[1] [2]}

References

1. ↑ Lehmacher A, Vogt AB, Hensel R. Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus. FEBS Lett. 1990 Oct 15;272(1-2):94-8. PMID:2226838 doi:10.1016/0014-5793(90)80456-s
2. ↑ Matussek K, Moritz P, Brunner N, Eckerskorn C, Hensel R. Cloning, sequencing, and expression of the gene encoding cyclic 2, 3-diphosphoglycerate synthetase, the key enzyme of cyclic 2, 3-diphosphoglycerate metabolism in Methanothermus fervidus. J Bacteriol. 1998 Nov;180(22):5997-6004. PMID:9811660 doi:10.1128/JB.180.22.5997-6004.1998