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8poi is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
SPF30_HUMAN Necessary for spliceosome assembly. Overexpression causes apoptosis.[1][2][3]
References
↑ Talbot K, Miguel-Aliaga I, Mohaghegh P, Ponting CP, Davies KE. Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complex. Hum Mol Genet. 1998 Dec;7(13):2149-56. PMID:9817934
↑ Meister G, Hannus S, Plottner O, Baars T, Hartmann E, Fakan S, Laggerbauer B, Fischer U. SMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome. EMBO J. 2001 May 1;20(9):2304-14. PMID:11331595 doi:http://dx.doi.org/10.1093/emboj/20.9.2304
↑ Rappsilber J, Ajuh P, Lamond AI, Mann M. SPF30 is an essential human splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. J Biol Chem. 2001 Aug 17;276(33):31142-50. Epub 2001 Apr 30. PMID:11331295 doi:http://dx.doi.org/10.1074/jbc.M103620200