8pr4

Structural highlights

Function

ARP10_PIG Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.^{[1] [2]}

References

1. ↑ Lau CK, O'Reilly FJ, Santhanam B, Lacey SE, Rappsilber J, Carter AP. Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end. EMBO J. 2021 Apr 15;40(8):e106164. PMID:33734450 doi:10.15252/embj.2020106164
2. ↑ Chaaban S, Carter AP. Structure of dynein-dynactin on microtubules shows tandem adaptor binding. Nature. 2022 Sep 7. pii: 10.1038/s41586-022-05186-y. doi:, 10.1038/s41586-022-05186-y. PMID:36071160 doi:http://dx.doi.org/10.1038/s41586-022-05186-y