8qdo

Structural highlights

Function

PP71_HCMVA Stimulates viral immediate-early (IE) transcription. Plays a role in the inhibition of the host innate repsonse by targeting STING1 and thus the cGAS-STING pathway (PubMed:28132838, PubMed:32581105). Counteracts also host DAXX-mediated repression of viral transcription. Displaces a DAXX-binding protein, ATRX, from nuclear domain 10 sites (ND10) shortly after infection (PubMed:18922870). Increases the basal level of SUMOylated DAXX in infected cells (PubMed:19369322). Stimulates quiescent cells to re-enter the cell cycle, proceed through G1 and enter the S phase (PubMed:12610120). Interacts with hypophosphorylated forms of RB1 and induces their degradation by the proteasome without involving ubiquitin conjugation (PubMed:12626766).^{[1] [2] [3] [4] [5] [6]}

References

1. ↑ Kalejta RF, Shenk T. The human cytomegalovirus UL82 gene product (pp71) accelerates progression through the G1 phase of the cell cycle. J Virol. 2003 Mar;77(6):3451-9. PMID:12610120 doi:10.1128/jvi.77.6.3451-3459.2003
2. ↑ Kalejta RF, Shenk T. Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3263-8. PMID:12626766 doi:10.1073/pnas.0538058100
3. ↑ Lukashchuk V, McFarlane S, Everett RD, Preston CM. Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection. J Virol. 2008 Dec;82(24):12543-54. PMID:18922870 doi:10.1128/JVI.01215-08
4. ↑ Hwang J, Kalejta RF. Human cytomegalovirus protein pp71 induces Daxx SUMOylation. J Virol. 2009 Jul;83(13):6591-8. PMID:19369322 doi:10.1128/JVI.02639-08
5. ↑ Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB. Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity. Cell Host Microbe. 2017 Feb 8;21(2):231-243. PMID:28132838 doi:10.1016/j.chom.2017.01.001
6. ↑ Nukui M, Roche KL, Jia J, Fox PL, Murphy EA. Protein S-Nitrosylation of Human Cytomegalovirus pp71 Inhibits Its Ability To Limit STING Antiviral Responses. J Virol. 2020 Aug 17;94(17):e00033-20. PMID:32581105 doi:10.1128/JVI.00033-20