Structural highlights
Function
A0A8D1DPV6_PIG DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[RuleBase:RU004279]
Publication Abstract from PubMed
Transcription by RNA polymerase II (Pol II) can be repressed by noncoding RNA, including the human RNA Alu. However, the mechanism by which endogenous RNAs repress transcription remains unclear. Here we present cryogenic-electron microscopy structures of Pol II bound to Alu RNA, which reveal that Alu RNA mimics how DNA and RNA bind to Pol II during transcription elongation. Further, we show how distinct domains of the general transcription factor TFIIF control repressive activity. Together, we reveal how a noncoding RNA can regulate mammalian gene expression.
Mechanism of mammalian transcriptional repression by noncoding RNA.,Tluckova K, Kaczmarek B, Salmazo A, Bernecky C Nat Struct Mol Biol. 2025 Jan 6. doi: 10.1038/s41594-024-01448-7. PMID:39762629[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Tlučková K, Kaczmarek B, Salmazo A, Bernecky C. Mechanism of mammalian transcriptional repression by noncoding RNA. Nat Struct Mol Biol. 2025 Jan 6. PMID:39762629 doi:10.1038/s41594-024-01448-7
