8qmd

Structural highlights

Function

KLRF1_HUMAN Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases (PubMed:21149606).^{[1] [2]}

References

1. ↑ Welte S, Kuttruff S, Waldhauer I, Steinle A. Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction. Nat Immunol. 2006 Dec;7(12):1334-42. PMID:17057721 doi:10.1038/ni1402
2. ↑ Dennehy KM, Klimosch SN, Steinle A. Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity. J Immunol. 2011 Jan 15;186(2):657-61. PMID:21149606 doi:10.4049/jimmunol.0904117