Structural highlights
Function
SAD_ECOLI Catalyzes the NAD(+)-dependent oxidation of succinate semialdehyde to succinate. It acts preferentially with NAD as cosubstrate but can also use NADP. Prevents the toxic accumulation of succinate semialdehyde (SSA) and plays an important role when arginine and putrescine are used as the sole nitrogen or carbon sources.[1] [2] [3] [4]
References
- ↑ Fuhrer T, Chen L, Sauer U, Vitkup D. Computational prediction and experimental verification of the gene encoding the NAD+/NADP+-dependent succinate semialdehyde dehydrogenase in Escherichia coli. J Bacteriol. 2007 Nov;189(22):8073-8. PMID:17873044 doi:10.1128/JB.01027-07
- ↑ Kurihara S, Kato K, Asada K, Kumagai H, Suzuki H. A putrescine-inducible pathway comprising PuuE-YneI in which gamma-aminobutyrate is degraded into succinate in Escherichia coli K-12. J Bacteriol. 2010 Sep;192(18):4582-91. doi: 10.1128/JB.00308-10. Epub 2010 Jul, 16. PMID:20639325 doi:http://dx.doi.org/10.1128/JB.00308-10
- ↑ Donnelly MI, Cooper RA. Two succinic semialdehyde dehydrogenases are induced when Escherichia coli K-12 Is grown on gamma-aminobutyrate. J Bacteriol. 1981 Mar;145(3):1425-7. PMID:7009588 doi:10.1128/jb.145.3.1425-1427.1981
- ↑ Donnelly MI, Cooper RA. Succinic semialdehyde dehydrogenases of Escherichia coli: their role in the degradation of p-hydroxyphenylacetate and gamma-aminobutyrate. Eur J Biochem. 1981 Jan;113(3):555-61. PMID:7011797
