Structural highlights
8qsj is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | Electron Microscopy, Resolution 3Å |
| Ligands: | , , , , , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
RM32_HUMAN
Publication Abstract from PubMed
Mitochondria contain their own genetic information and a dedicated translation system to express it. The mitochondrial ribosome is assembled from mitochondrial-encoded RNA and nuclear-encoded ribosomal proteins. Assembly is coordinated in the mitochondrial matrix by biogenesis factors that transiently associate with the maturing particle. Here, we present a structural snapshot of a large mitoribosomal subunit assembly intermediate containing 7 biogenesis factors including the GTPases GTPBP7 and GTPBP10. Our structure illustrates how GTPBP10 aids the folding of the ribosomal RNA during the biogenesis process, how this process is related to bacterial ribosome biogenesis, and why mitochondria require two biogenesis factors in contrast to only one in bacteria.
Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.,Nguyen TG, Ritter C, Kummer E Nat Commun. 2023 Dec 2;14(1):7991. doi: 10.1038/s41467-023-43599-z. PMID:38042949[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Nguyen TG, Ritter C, Kummer E. Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome. Nat Commun. 2023 Dec 2;14(1):7991. PMID:38042949 doi:10.1038/s41467-023-43599-z
