Structural highlights
Function
RNAS1_BOVIN Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.[1]
Publication Abstract from PubMed
Here, we present for the first time the synthesis of P-stereodefined morpholino phosphorothioate analogs by using a modified 1,3,2-oxathiaphospholane method (OTP method) and provide valuable structural insights into their stereochemistry. N-(2-Thio-4,4-pentamethylene-1,3,2-oxathiaphospholane) derivatives of morpholino-type nucleosides (mU-OTPs) were synthesized, separated into pure P-diastereomers and used to prepare P-stereodefined morpholino dinucleoside 3',5'-phosphorothioates.
P-Stereodefined morpholino dinucleoside 3',5'-phosphorothioates.,Jastrzebska K, Antonczyk P, Dolot R Org Biomol Chem. 2024 Oct 11. doi: 10.1039/d4ob01437e. PMID:39392463[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ delCardayre SB, Ribo M, Yokel EM, Quirk DJ, Rutter WJ, Raines RT. Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11. Protein Eng. 1995 Mar;8(3):261-73. PMID:7479688
- ↑ Jastrzębska K, Antończyk P, Dolot R. P-Stereodefined morpholino dinucleoside 3',5'-phosphorothioates. Org Biomol Chem. 2024 Oct 11. PMID:39392463 doi:10.1039/d4ob01437e
