8rqt

Structural highlights

Function

PEX8_PICPA Essential component of the machinery required for the import of both PTS1 and PTS2 (and perhaps all) peroxisomal matrix proteins (PubMed:7738036). Binding of PEX8 to the N-terminus of PEX5 cargo receptor induces a conformational change of the TPR domains and decrease their binding affinity to cargo, facilitating the release of the PTS1 proteins within the peroxisome (PubMed:23902771).^{[1] [2]}

References

1. ↑ Ma C, Hagstrom D, Polley SG, Subramani S. Redox-regulated cargo binding and release by the peroxisomal targeting signal receptor, Pex5. J Biol Chem. 2013 Sep 20;288(38):27220-27231. PMID:23902771 doi:10.1074/jbc.M113.492694
2. ↑ Liu H, Tan X, Russell KA, Veenhuis M, Cregg JM. PER3, a gene required for peroxisome biogenesis in Pichia pastoris, encodes a peroxisomal membrane protein involved in protein import. J Biol Chem. 1995 May 5;270(18):10940-51. PMID:7738036 doi:10.1074/jbc.270.18.10940