8rwb

Structural highlights

Function

ULBP6_HUMAN Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.^{[1] [2]}

References

1. ↑ Eagle RA, Traherne JA, Hair JR, Jafferji I, Trowsdale J. ULBP6/RAET1L is an additional human NKG2D ligand. Eur J Immunol. 2009 Nov;39(11):3207-16. PMID:19658097 doi:10.1002/eji.200939502
2. ↑ Zuo J, Willcox CR, Mohammed F, Davey M, Hunter S, Khan K, Antoun A, Katakia P, Croudace J, Inman C, Parry H, Briggs D, Malladi R, Willcox BE, Moss P. A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding. Sci Signal. 2017 May 30;10(481). pii: eaai8904. doi: 10.1126/scisignal.aai8904. PMID:28559451 doi:http://dx.doi.org/10.1126/scisignal.aai8904