8s6u

Structural highlights

Function

UPA1_USTMA FYVE zinc finger domain protein that functions in endosomal targeting and transport of mRNAs, as well as associated ribosomes (PubMed:25985087, PubMed:28422978). The endosomal mRNA transport regulates polarity of the infectious hyphae by transporting a broad spectrum of cargo mRNAs from the nucleus to cell poles (PubMed:25985087). Involved in chitinase CTS1 secretion (PubMed:25985087). Dispensable for general endosomal functions but crucial for endosomal recruitment of RRM4 (PubMed:25985087).^{[1] [2]}

References

1. ↑ Pohlmann T, Baumann S, Haag C, Albrecht M, Feldbrugge M. A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking. Elife. 2015 May 18;4. doi: 10.7554/eLife.06041. PMID:25985087 doi:http://dx.doi.org/10.7554/eLife.06041
2. ↑ Haag C, Pohlmann T, Feldbrügge M. The ESCRT regulator Did2 maintains the balance between long-distance endosomal transport and endocytic trafficking. PLoS Genet. 2017 Apr 19;13(4):e1006734. PMID:28422978 doi:10.1371/journal.pgen.1006734